Release Profiles of Dyes and Proteins from Calcium Phosphate Microspheres with Different Crystalline Phases

Calcium phosphate is attracting attention as a bone repair material and controlled-release carrier of various drugs such disease therapeutic agents anticancer agents. Compared with some bioabsorbable polymers, calcium phosphates have the advantage preventing pH decrease in surrounding body fluid. However, there are few studies comparing effect supporting substances different physicochemical properties on production microspheres crystalline phases. In this study, we investigated conditions for obtaining low crystallinity apatite octacalcium (OCP) from carbonate structures using simple phosphoric acid treatment. Furthermore, adsorption release behavior dyes proteins OCP microspheres. Overall, factors governing depending molecular size surface charge dye protein adsorbates.